BDBM50358430 CHEMBL1614725

SMILES CC(C)(O)CC(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4cccc(c4)C(F)(F)F)c(Cl)c3)c12

InChI Key InChIKey=ZYQXEVJIFYIBHZ-UHFFFAOYSA-N

Data  39 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50358430   

TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of C-terminal His6-tagged HER2 (703 to 1029 residues) (unknown origin) expressed in Sf9 insect cells using TK as substrate preincubated fo...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Korea University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50:  1nMAssay Description:Inhibition of [3H]-diprenorphine binding to kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50:  3nMAssay Description:Inhibition of [3H]-diprenorphine binding to kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50:  17nMAssay Description:Inhibition of human N-terminus peptide (DYKDDDD)-tagged HER2 expressed in baculovirus infected insect cells using [gamma-32P]ATP as substrate after 6...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Korea University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50:  4nMAssay Description:Inhibition of human wild type EGFR expressed in Sf9 cells using [gamma32P]-ATP after 10 mins by scintillation countingMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Korea University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50:  23nMAssay Description:Inhibition of human N-terminal DYKDDDD-tagged EGFR cytoplasmic domain (669 to 1210) expressed in baculovirus expression system incubated for 5 mins p...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50:  17nMAssay Description:Inhibition of human N-terminal DYKDDDD-tagged HER2 cytoplasmic domain (676 to 1255) expressed in baculovirus expression system incubated for 5 mins p...More data for this Ligand-Target Pair